ENZYSYSTEM
Our product allows for ambulant multi-parameter blood coagulation analysis.
Our product allows for ambulant multi-parameter blood coagulation analysis.
The challenge is to make a truly portable device, with a cartridge that includes reagents to perform a number of clinically relevant tests, including controls, that has the same quality as tests performed in a specialized hospital laboratory at equivalent costs. Furthermore, the results need to be made available to the attending physician whether he or she is on location or in hospital.
The first target market for the ENZYSYSTEM technology is Hemophilia patients to monitor their blood coagulation. This well-defined patient population is well aware of the bleeding risks and associated complications that clearly require to have more frequent analysis of blood coagulation so therapy can be adjusted timely. We estimate this market to be about €25-50M.
ENZYCARDs are small microfluidic cartridges that slide into the ENZYPAD processor and contain all the reagents and controls to perform up to sixteen reactions. The first ENZYSYSTEM products will be focused on blood coagulation, the core expertise of the company. The technology can however be applied more broadly in collaboration with partners with expertise in different fields.
The ENZYSYSTEM uses chemiluminescent technology in combination with high performance nano-optical sensors to detect biomarker activity in sub microliter volumes of blood, allowing the desired quality at the acceptable costs. The test results can be immediately encrypted and transferred to the cloud where anyone with the appropriate credentials can access them.
Several business cases have been identified for the device: diagnosis and monitoring of bleeding disorders, monitoring of the hemostatic balances in critical care setting such as in the operating room, intensive care unit & emergency room, and the detection and reversal of anti-coagulant therapy.
ENZYCARDs use proprietary substrates that can be processed by luciferase and generate light when cleaved. Patents to this technology have been granted in EU, US & JP. By using chemiluminescent technology in combination with nano-optical sensors, there is no need for a light source or filters allowing the reduction of the size of the instrument. In turn, this allows the use of microfluidic channels and sub-microliter reagent reservoirs that enable to run up to sixteen assays in a single device.
EnzySystem means certainty about patients’ individual risk to develop a bleed. Analysis can be performed when the need arises. There is no more need to travel to the clinic to manage their disease. This ensures greater mental comfort, as they will have great control of their disease. It also means less complications due to optimized treatment.
With the EnzySystem, physicians and healthcare workers can provide better care without additional effort. It also allows them to manage the patient’s anomaly based on patient real-time data. Lastly, they are able to help more patients through telemedicine.
Pharmaceutical companies can offer optimized therapy, causing increased customer satisfaction. They can retain and/or increase market share, and increase the TAM for the therapy to regions where access to lab-based tests is limited.
Optimized therapy means less complications and less hospital visits. Also, one doctor can help more patients.
Enzyre is always looking for collaborations to expand use of its platform technologies. Interested parties are encouraged to contact us at info@enzyre.com.
Get involved
Enzyre BV
Transistorweg 5
6534-AT Nijmegen
The Netherlands
